To evaluate the quality of life (QoL) of patients with pituitary adenoma following Endoscopic Endonasal Transsphenoidal Surgery (EETS) and identify factors influencing long-term outcomes.

A cross-sectional study was conducted at the National Brain Center Hospital, Indonesia. Secondary data were obtained from medical records and the pituitary registry, while primary data were collected through patient interviews using the validated Indonesian version of the SF-36 questionnaire. Statistical analyses included univariate, bivariate, and multivariate linear regression with the backward method to identify independent predictors of QoL.

Among 90 patients (45 males, 45 females), visual disturbances (85.6%) and hormonal deficiencies (93.3%) were common. Most had macroadenomas (95.6%) and received combined EETS and medical therapy (62.2%). Physical component scores (PCS) exceeded mental component scores (MCS). The highest domain scores were in physical functioning and role-emotional functioning; vitality and mental health had the lowest scores. Gender was significantly associated with four QoL domains, and hormonal deficiency affected the role-emotional domain. Multivariate analysis identified gender and hormonal deficiency as predictors of MCS (R² = 74%); no factors significantly influenced PCS.

Postoperative QoL after EETS is generally good in physical aspects but suboptimal in mental health. Gender and hormonal deficiency affect mental QoL, highlighting the need for holistic, long-term care strategies.

Background Median pancreatectomy (MP) is a parenchyma-sparing procedure for benign and low-grade malignant lesions of the pancreatic neck and body, with the potential to preserve endocrine and exocrine function. However, concerns regarding postoperative pancreatic fistula (POPF) have limited its widespread adoption. Methods This retrospective cohort study included 23 consecutive patients who underwent MP at a tertiary referral centre between January 2015 and December 2025. POPF was classified using the 2016 International Study Group of Pancreatic Surgery criteria, and long-term endocrine and exocrine function was assessed during follow-up. Results The mean age was 43.57 ± 15.05 years, and 91.3% of the patients were female. Common indications included cystic neoplasms (60.9%), neuroendocrine tumours (21.7%), and solid pseudopapillary neoplasms. Biochemical leak occurred in 60.9% of patients, and Grade B POPF occurred in 30.4%. Patients with Grade B POPF had a significantly longer hospital stay than those with biochemical leak (25.00 ± 15.41 vs. 14.29 ± 7.53 days, p = 0.039). No mortality was observed. At a median follow-up of 98 months (range, 4-130 months), only one patient (4.3%) developed new-onset diabetes, and none developed exocrine insufficiency. Conclusion MP is a safe and effective parenchyma-sparing procedure with excellent long-term preservation of pancreatic function, despite the high incidence of biochemical leak and Grade B POPF, which can generally be managed conservatively with appropriate clinical care.

Primary synovial sarcoma of the prostate is exceptionally rare. Its nonspecific presentation and often normal or low prostate-specific antigen (PSA) levels may delay diagnosis. A 49-year-old man presented with lower urinary tract symptoms and gross hematuria. Digital rectal examination revealed a markedly enlarged, firm, irregular prostate. The serum PSA level was 0.34 ng/mL. Pelvic magnetic resonance imaging showed a 9.4 × 7.4 × 6.5 cm heterogeneous prostatic mass with loss of the rectoprostatic fat plane, without definitive evidence of metastatic disease on staging. Transrectal ultrasound-guided biopsy demonstrated a monophasic spindle-cell neoplasm with immunohistochemical findings consistent with synovial sarcoma. Robot-assisted radical prostatectomy was converted to an open approach to facilitate resection. Tumor was identified in tissue from the rectoprostatic margin, while the overall margin status was indeterminate because of tumor fragmentation, raising concern for microscopic residual disease. The patient received adjuvant pelvic radiotherapy followed by doxorubicin and ifosfamide chemotherapy. At 20 months, he remained alive without radiologic evidence of recurrence or metastasis. Primary prostatic synovial sarcoma should be considered in younger to middle-aged patients with obstructive urinary symptoms, a large prostatic mass, and a normal or low PSA level. Diagnosis relies on histopathologic assessment, supported by immunohistochemistry and molecular testing whenever available. Management should be individualized through multidisciplinary discussion.

Hepatocellular carcinoma (HCC) and transcatheter arterial chemoembolisation (TACE) are physically demanding for patients and their caregivers, as well as psychologically stressful. Spouses are often the main informal caregivers, so illness-related stress after TACE is experienced by the couple. Hope can provide psychological support for people with cancer, and dyadic coping refers to how couples cope with the stress of illness through communication. However, evidence remains limited regarding actor and partner associations between hope and dyadic coping in HCC patient-spouse dyads after TACE.

To examine the actor and partner associations between hope and dyadic coping in HCC patient-spouse dyads after TACE using the actor-partner interdependence model (APIM).

This cross-sectional study included 177 patient-spouse dyads recruited from a tertiary hospital in China between October 2023 and June 2024. Participants completed questionnaires on hope and dyadic coping. Data were analysed using SPSS 25.0 and AMOS 24.0. Distinguishable dyads were specified in the APIM, controlling for patient age, Child-Pugh grade, and number of TACE sessions.

Both patients and their spouses reported moderate dyadic coping and relatively high hope. Hope was positively correlated with dyadic coping within and between partners. APIM revealed significant actor associations, indicating that higher hope was associated with better individual dyadic coping in patients (B' = 0.289, 95% CI [0.109, 0.451], p < 0.001) and spouses (B' = 0.381, 95% CI [0.221, 0.521], p < 0.001). Significant partner associations were also observed from patients to spouses (B' = 0.160, 95% CI [0.001, 0.308], p < 0.05) and from spouses to patients (B' = 0.181, 95% CI [0.031, 0.322], p < 0.05). These findings suggest that hope is associated with dyadic coping in both patients and spouses, underscoring the interdependent nature of psychological adjustment among couples managing HCC after TACE.

Hope was associated with dyadic coping in both patients and spouses, highlighting the interdependent nature of psychological adjustment in couples coping with HCC after TACE.

Nurse managers should recognise HCC patient-spouse dyads as an interdependent unit and incorporate assessment of both partners' hope and dyadic coping into oncology care management.

Priority-setting partnerships (PSPs) are used to identify research questions that matter most to patients, caregivers, and clinicians. However, submissions that fall outside the scope of research prioritisation are rarely examined despite their potential to reveal important unmet needs. This study explored concerns relevant to practice and policy using the out-of-scope questions submitted during the Australian Child and Adolescent Cancer PSP.

We conducted the Australian Child and Adolescent Cancer PSP with the James Lind Alliance to identify research priorities for childhood cancer. An online national survey collected submissions from children and adolescents diagnosed with cancer, their caregivers, and healthcare professionals. We identified submissions that fell outside the PSP scope. These were collated and analysed using qualitative content analysis, followed by framework analysis to deductively map themes to the World Health Organisation Health System Building Blocks, enabling system-level interpretation of community-identified concerns.

Of the 701 submissions, 99 (14%) were classified as out-of-scope and included in this analysis. Seventy-two respondents contributed to these submissions, most of whom were caregivers (n = 58, 81%). Themes mapped across the WHO building blocks, including treatment access, research innovation and translation, health financing, service delivery and environment of care, leadership and governance, health information and communication, and health workforce. Additional concerns were classified as dimensions of care.

Out-of-scope PSP submissions provide valuable insights into patient, caregiver, and clinician concerns that complement research priorities. They highlight persistent challenges in access to care, supportive services, workforce capacity, information provision, and financial burden, underscoring that many family concerns stem from gaps in implementation, service delivery, and policy, rather than evidence alone. These system-level challenges must be communicated to funders, policymakers, charities, and consumers to translate these insights into meaningful improvements in care.

A 79-year-old woman with a history of endovascular aneurysm repair (EVAR) for a large abdominal aortic aneurysm underwent robot-assisted ileocecal resection (R-ICR) for ascending colon cancer. Several technical modifications, including modified port placement, operative sequence adjustment, and strict intraoperative blood pressure control, were implemented to minimize inadvertent stress on the stent graft. The procedure was completed without vascular complications, and the postoperative course was uneventful. Although robot-assisted surgery increases the risk of mechanical aneurysmal compression and lacks tactile feedback, these technical modifications enabled safe procedural completion. R-ICR after EVAR with appropriate technical modifications and perioperative management may be feasible in select patients.

This study aims to summarize literature about barriers and facilitators to participation in the breast cancer screening (BCS) activities among Palestinian women living in the West Bank or Gaza Strip to which could direct future research and guide policymakers and stakeholders for proper interventions.

We conducted a literature review guided by the Arksey and O'Malley framework. PubMed, Scopus, and Google Scholar were searched from database inception to May 2025 without restrictions on language or publication date. Original studies examining barriers and/or facilitators related to breast cancer screening and early-detection practices among Palestinian women living in the West Bank or Gaza Strip were eligible. Two reviewers independently screened the records, and disagreements were resolved by a third reviewer. Data were charted using a predefined form. Without restrictions on language or publication date. After data extraction, reported barriers were grouped inductively into five overarching categories based on conceptual similarity. Facilitators were charted separately as factors associated with greater screening uptake or screening practice.

Low participation in BCS services was reported by several studies. Personal and cultural barriers such as embarrassment, fear of cancer diagnosis, not being a priority, and lack of time were highly reported. Other health care system, socioeconomic, knowledge-based, and geographical barriers such as male healthcare providers, perceived lower risk of cancer, unawareness of breast cancer screening services, cost, and difficulty reaching clinics were also reported by several studies. Meanwhile, good knowledge about BCS services, perceived benefit of early detection, receiving referrals from NGOs or hospitals, being employed or married, and living in a city were some of the reported facilitators.

Health organizations, policymakers, and stakeholders can use this literature as a comprehensive source that summarizes the attitudes of Palestinian women toward BCS services, which could guide them in proper interventions, initiatives, and identifying opportunities for future research.

To investigate the clinical characteristics and diagnostic approaches for patients with primary gastric large B-cell lymphoma with IRF4 rearrangements (LBCL-IRF4), thereby enhancing understanding of this distinct subtype.

A retrospective analysis was conducted on the clinical presentation, diagnostic and therapeutic course, and prognosis of this single case of primary gastric LBCL-IRF4 treated in our hospital.

Based on pathological, imaging, and bone marrow examinations, the patient was diagnosed with LBCL-IRF4 (Stage ⅡA, IPI score: 1, low risk; NCCN-IPI score: 2, intermediate-low risk; CNS score: 1, low risk). The patient received four cycles of the R-CDOP regimen (rituximab + cyclophosphamide + vindersine + liposomal doxorubicin + prednisolone tablets) followed by two additional cycles of rituximab consolidation therapy. The patient achieved complete remission.

LBCL-IRF4 is clinically uncommon, and primary gastric LBCL-IRF4 is even rare. Such patients demonstrate favourable outcomes following standard treatment.

Mediastinal staging is crucial in patients undergoing lung resection for cancer to plan further adjuvant. Current guidelines recommend resecting at least three mediastinal lymph node stations, including Group7. Herein, we evaluated the role of intraoperative Contrast-enhanced ultrasound (CEUS) to guide lymph node resection in patients undergoing RATS lobectomy for management of non-small cell lung cancer.

It was a retrospective study including 24 consecutive patients underwent RATS lobectomy for management lung cancer. The hilar and mediastinal lymph node was firstly evaluated with a CEUS and then resected. A bolus of 2.4 mL SonoVue was injected into the antecubital vein and the perfusion was scanned continuously for at least 3 min. The dynamic image obtained was used to evaluate the mediastinal and hilar lymph nodal and guide the dissection. A radical lymph-adenectomy was performed in all cases independently from the CEUS results.

We evaluated 144 lymph nodes with a CEUS during RATS lobectomy. Histological examination of the lymph nodes showed five lymph nodes metastatic (3.5%); of which 3 (60%) metastatic N1 lymph nodes; 2 (40%) metastatic N2 lymph nodes. Intraoperative CEUS of hilar and mediastinal lymph nodes showed: sensitivity 83%; specificity 98%; PPV, 77%; PNV, 99% and accuracy 94%.

Our preliminary results seem to confirm the value of intraoperative CEUS to assess lymph node resection during RATS lobectomy. It may help the lymph node dissection and reduce the risk of intraoperative injury. Future study should confirm our preliminary results and confirm the value of intraoperative CEUS.

This study was conducted to investigate the effect of emotional freedom techniques (EFT) on death anxiety in patients experiencing postsurgery cancer-related anxiety. A total of 120 oncological surgical patients were randomly allocated to either the intervention group (n = 60) or the control group (n = 60). Data were collected from February 2025 to September 2025 as a randomized controlled trial. While EFT (once a day, for 3 days) was applied to the patients in the intervention group in addition to the clinical procedure, the control group only followed the clinical procedure without any intervention. Following EFT, participants in the intervention group showed statistically significant reductions in both cancer-related anxiety and death anxiety scores (p < 0.001). The decrease in subjective distress scores in the intervention group after EFT was found to be significant (p < 0.001). When the intervention and control groups were compared based on their final test scores, the intervention group had lower levels of cancer-related anxiety, death anxiety, and subjective distress (p < 0.05). Clinical EFT application demonstrated immediate postintervention efficacy in reducing death anxiety, cancer-related anxiety, and subjective distress. However, due to the absence of a long-term follow-up period, these findings reflect acute psychological stabilization.