This study aimed to analyze respiratory-induced tumor motion characteristics in different lung lobes based on four-dimensional computed tomography (4DCT) images and explore the relationship between respiratory rates and respiratory-induced tumor motion amplitudes of different lung lobes.

The clinical data of 79 patients with 91 lesions who underwent 4DCT scans from 2023 to 2024 at Zhongshan Hospital Fudan University were retrospectively analyzed. Tumors were divided into five groups based on tumor location: left upper lobe group (group A, n = 21), left lower lobe group (group B, n = 23), right upper lobe group (group C, n = 24), right middle lobe group (group D, n = 5), and right lower lobe group (group E, n = 18). Respiratory-induced tumor motion amplitudes were compared among the five groups using one-way analysis of variance. Bivariate linear correlation and receiver operating characteristic curve were used to analyze the relationship between respiratory rates and respiratory-induced tumor motion amplitudes.

The respiratory-induced tumor motion amplitudes of lung tumors in the left-right (LR), superior-inferior (SI), and anterior-posterior (AP) directions were 2.34 ± 1.13 mm, 7.80 ± 7.01 mm, and 3.61 ± 2.10 mm, respectively. In the SI direction, the respiratory-induced tumor motion amplitudes for groups A, B, C, D, and E were 4.33 ± 4.16 mm, 12.39 ± 5.86 mm, 2.75 ± 2.56 mm, 7.20 ± 3.35 mm, and 12.89 ± 8.76 mm, respectively ( P < 0.001). A negative correlation was found between the mean respiratory rate and the respiratory-induced tumor motion amplitude in the LR direction ( r = -0.630, P = 0.005) and SI direction ( r = -0.622, P = 0.006) in group E.

The respiratory-induced tumor motion amplitudes of different lung lobes are not the same, with lower lobe tumors having the largest motion amplitude and upper lobe tumors having the smallest motion amplitude. In addition, the respiratory-induced motion amplitude of right lower lobe tumors decreases with the increase of respiratory rate.

The ADRIATIC trial has established durvalumab as a new standard of care for limited-stage small-cell lung cancer (LS-SCLC) by showing significant survival benefits after chemoradiotherapy (CRT). In this study, the cost-effectiveness of this regimen was evaluated from Chinese and U.S. payer perspectives.

A partitioned survival model was used to estimate the lifetime costs and quality-adjusted life-years (QALYs) of patients receiving durvalumab compared with placebo after CRT. Data were sourced from the ADRIATIC trial. Outcomes included incremental cost-effectiveness ratios (ICERs), with uncertainty assessed via deterministic and probabilistic sensitivity analyses (PSAs).

In the base-case analysis for China, the ICER was $136,209.12 per QALY, which exceeds the $40,334.05 willingness-to-pay (WTP) threshold. For the U.S., the ICER was $214,184.71 per QALY, which is higher than the $150,000 WTP threshold. However, under the Chinese patient assistance program (PAP), the ICER decreased to $18,495.23 per QALY, making it cost-effective. Subgroup analysis revealed cost-effectiveness only in the U.S. carboplatin subgroup (ICER: $139,909.75 per QALY). PSA confirmed a low probability of cost-effectiveness (0-5.33%) in base-case scenarios, which increased to 99.93% under the Chinese PAP.

At present, durvalumab consolidation therapy is not considered cost-effective for LS-SCLC in either country at the current WTP threshold. However, the Chinese PAP renders it a cost-effective option, highlighting the critical role of pricing and patient access programs.

To validate the accuracy and reliability of the microwave ablation (MWA) planning system in predicting the postablation target zone (PTZ) in lung tumors after computed tomography (CT)-guided MWA and analyze its potential influencing factors.

A retrospective analysis of 118 patients with 134 lung tumors, who underwent CT-guided MWA from May 2020 to September 2021, was conducted. CT images were collected at 24 hours and 1 month after MWA to evaluate the local effect and complications. The differences between the size and shape of the actual PTZ and predicted ones were compared, and the factors affecting PTZ were also analyzed.

The predicted long diameters, short diameters, and spherical index (SI) of PTZ detected at 24 hours after MWA were basically consistent with the actual ones, but significantly larger than those detected at 1 month after MWA, and the difference was more pronounced in the short diameter than in the long diameter. The lesion diameter and ablation power had an independent effect on the ablation index (AI) at 24 hours after MWA ( P < 0.05), and there was a significant difference in AI between invasive adenocarcinoma and atypical adenomatoid hyperplasia at 24 hours after MWA ( P < 0.05).

The size and shape of the PTZ predicted by MWA planning system were basically consistent with the actual ones detected at 24 hours after MWA. However, by 1 month, the predicted values of the long diameter, short diameter, and SIs were all significantly higher than the actual ones. PTZ is positively correlated with lesion size and ablation power, and different pathological types can also affect the ablation zone.

Selective estrogen receptor modulators (SERMs) have certain effects on lipid metabolism; however, the results of various studies remain controversial. We conducted a meta-analysis to summarize the existing evidence from cohort studies and randomized controlled trials (RCTs) on the effect of SERM treatment on lipid metabolism in breast cancer patients.

We conducted a comprehensive search of PubMed, Embase, Cochrane, EBSCO, and the Web of Science databases through January 31, 2026, to identify articles focused on the effects of SERMs on lipid metabolism. Each study included the effect size and 95% confidence interval (95% CI) of the relationship between SERMs and lipid metabolism. Subgroup analyses were also performed to explore potential.

A total of 19 studies (13 RCTs and 6 cohort studies) were included in the meta-analysis. SERMs showed significant differences from other breast cancer treatment methods in terms of total cholesterol (TC) (SMD = -0.70; 95% CI: -0.91, -0.50), triglycerides (TG) (SMD = 0.32; 95% CI: 0.06, 0.59), low-density lipoprotein (LDL-C) (SMD = -0.76; 95% CI: -1.02, -0.50), and the risk of fatty liver occurrence (RR = 1.57; 95% CI: 1.13, 2.18).

SERMs exhibited significant efficacy in lowering LDL-C and TC; however, they may increase the risk of developing fatty liver. Clinical decision-making should involve a comprehensive evaluation of individual patient characteristics to optimize personalized treatment strategies.

​The uncovering the long-term impact of oropharyngeal cancer and dysphagia on dietary quality and nutrition among cancer survivors (U-DINE) Study is a multisite longitudinal investigation of diet quality and nutritional risk across the oropharyngeal cancer (OPC) care continuum. U-DINE integrates dietary, clinical, and swallowing assessments from two clinical cohorts. Adults with primary, non-recurrent OPC are assessed at diagnosis, 3-6 months post-treatment, and 18-24 months post-treatment using standardized 24-hour dietary recalls and measures of food and nutrition security, barriers to healthy eating, and malnutrition risk. Among 333 participants, poor diet quality was pervasive. Very low (HEI-2020 51-70) or critically low (HEI-2020 ≤50) diet quality was observed in 130 of 132 participants (98.5%) at diagnosis, 35 of 36 (97.2%) post-treatment, and 158 of 165 (95.8%) during long-term survivorship; none had adequate diet quality. Critically low diet quality was observed in 35 of 58 non-White versus 154 of 275 White participants (60.3% vs. 56.0%), 18 of 27 females versus 171 of 306 males (66.7% vs. 55.9%), and 163 of 283 participants with HPV-positive versus 16 of 29 with HPV-negative tumors (57.6% vs. 55.2%). Among post-treatment and long-term survivors, critically low diet quality was observed in 8 of 10 participants treated with surgery alone (80.0%), 72 of 125 receiving radiation and chemotherapy (57.6%), 17 of 33 receiving radiation only (51.5%), and 15 of 30 receiving surgery plus radiation with or without chemotherapy (50.0%). Overall, 14 participants (4.2%) were lost to follow-up or withdrew. U-DINE findings demonstrate pervasive poor diet quality across OPC survivorship and support the feasibility of comprehensive dietary assessment. Its longitudinal design provides a framework for identifying dietary risk and barriers to healthy eating and informing targeted interventions across the cancer care continuum.

This study aimed to investigate treatment patterns and survival outcomes in population-based data describing treatment and survival of primary vaginal carcinoma (VC) in a routine clinical setting, stratified by age group and stage.

This nationwide, population-based study included women diagnosed with epithelial VC between 2011 and 2020, registered in the Swedish Quality Register for Gynecologic Cancer. Five-year relative survival (RS) was estimated using the Pohar Perme method. The excess mortality rate ratio (EMRR) was assessed by Poisson regression.

In total, 252 women were identified, 29% were aged ≥ 80 years. The median follow-up time was 7.5 years. The most common stages were I and II (26% each). Definitive radiotherapy, with or without chemotherapy, was administered to 59% of patients. Among women with stage I, 48% underwent primary surgery and 29% received adjuvant radiotherapy. Treatment patterns differed across age groups. Among women aged ≥ 80 years, staging was omitted in 18%, and in stage I disease 25% received palliative therapy. None of the irradiated women aged ≥ 80 years received chemoradiotherapy, compared to all women aged 20-59 years. The overall 5-year RS for stages I-IV was 51% (95% confidence interval [CI] 43-58). In stages I-II, the 5-year RS was 28% among women aged ≥80 years and 84% among those aged < 60 years (EMRR of 5.2; 95% CI 1.7-15.6).

Primary treatment of vaginal cancer in Sweden generally followed international guidelines, except among women aged ≥ 80 years. The markedly poorer RS in this age group suggests both diagnostic and therapeutic compromises.

Colorectal cancer (CRC) is the second most common cancer in Malaysia, with most cases diagnosed at late stages, leading to poor survival. Stool-based screening methods, like the immunological faecal occult blood test (iFOBT), can reduce CRC mortality, but national uptake remains below 3%. This study explores barriers to CRC screening and their association with sociodemographic factors among adults aged 50 and above attending Seremban Health Clinic.

A cross-sectional study was conducted in March 2025 at Seremban Health Clinic, Negeri Sembilan, involving 400 adults aged 50 and above. Participants were selected through purposive sampling and completed a self-administered questionnaire adapted from the Scottish Bowel Screening Programme. Data analysis was performed using IBM SPSS version 28.0, with statistical methods including multiple linear regression.

The most frequently reported barriers included low self-efficacy, unfamiliarity with screening procedures, emotional concerns, and negative perceptions of screening. Age, gender, education level, employment status, and previous experience on cancer screening were found to have significant associations with barriers to cancer screening. Respondent's belief in early detection, a sense of health responsibility, and encouragement from healthcare providers and family were identified as facilitators to cancer screening. Prior screening experience was linked to fewer barriers.

Findings indicate the need for targeted interventions to improve awareness, confidence, and attitudes toward screening.

Cell-free DNA (cfDNA) has emerged as a promising non-invasive biomarker for cancer detection, including non-small cell lung cancer (NSCLC). While these approaches have demonstrated high diagnostic accuracy in controlled settings, their performance in real-world clinical populations remains uncertain. This study aimed to evaluate the diagnostic performance of a plasma cfDNA assay for early-stage NSCLC detection and to explore its association with clinicopathological parameters.

This was a single-center, crosssectional study involving 61 patients with radiologically suspected lung lesions, of whom 52 were confirmed NSCLC. Plasma samples were analyzed using a shallow genomewide sequencing-based cfDNA assay incorporating fragmentomic and copy number features. cfDNA results were compared against histopathological diagnosis to determine sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Associations between cfDNA detection and clinical variables were evaluated using appropriate statistical tests.

The cfDNA assay demonstrated a sensitivity of 75% and a PPV of 84.8% with a specificity of 22.2% and NPV of 13.3%. cfDNA detection rates increased with advancing disease stage, although a relatively high sensitivity was observed even in stage I disease (79.4%). No statistically significant associations were found between cfDNA positivity and conventional markers of tumour burden, including tumour size, serum carcinoembryonic antigen, and SUVmax.

The cfDNA assay evaluated in this study demonstrated limited clinical utility as a standalone screening tool due to its low specificity and NPV in a realworld early-stage NSCLC population. Future efforts should focus on improving assay specificity through the incorporation of multi-omic tumour-specific biomarkers and validation that includes early-stage lung cancer cases and benign pulmonary conditions.

Cervical cancer is the fourth most common malignancy in women. Approximately 15% of the patients have metastatic disease. The Malaysian National Cancer Registry (MNCR) 2017-2021 reported that over the five-year period, there were 2654 new cases. 47.1% of the patients presented with late stages (stages 3 and 4), slightly higher compared to 41% in the MNCR 2012-2016 report. There were no standard approaches to the management of metastatic/recurrent cervical cancer. Therefore, this study aimed to determine the survival outcomes of patients with metastatic/recurrent cervical cancer and to evaluate the clinicopathological factors based on demographic and tumour characteristics that may affect survival outcomes. Besides that, we would like to outline the management patterns in this cohort of patients.

This was a retrospective observational cohort study looking at the 35 patients diagnosed with metastatic/recurrent cervical cancer at the Department of Clinical Oncology, Universiti Malaya Medical Centre (UMMC) over the five-year period from 1st of January 2016 until 31st of December 2020. Data were obtained from the electronic medical record. The Kruskal-Wallis H and Mann-Whitney U non-parametric tests, Spearman correlation, and Kaplan-Meier survival analysis were conducted to analyse the survival outcomes and clinicopathological factors that may affect the survival outcomes in the form of progression-free survival (PFS) and overall survival (OS). Descriptive analysis was used to describe the prevalence of metastatic/recurrent cervical cancer and the patterns of management.

Out of the total 94 cervical cancer patients registered at the Department of Clinical Oncology, UMMC, 37.2% had metastatic/recurrent disease. Survival analysis demonstrated that median PFS and OS for metastatic/recurrent cervical cancer were six and 12 months, respectively, which were consistent with the global populations. Nonparametric multivariate tests and survival analysis showed that the presence of metastatic disease at less common sites had worse survival. Most of the patients received active oncological treatments, i.e., chemotherapy, radiotherapy or combinations of both.

This study showed that a significant portion of the patients were diagnosed at a late stage, with poor survival outcomes, indicating the necessity for enhanced initiatives in the screening and education programmes to increase awareness of early diagnosis and detection, hence improving survival outcomes of cervical cancer patients.

Chondroblastoma (CB) is a benign but locally aggressive bone tumor that may present histopathologic diagnostic challenges, particularly in atypical locations and limited biopsy specimens. Recent studies have identified recurrent mutations in the H3F3B and, less frequently, H3F3A genes, suggesting their potential diagnostic value. This study aimed to evaluate the prevalence and diagnostic utility of H3F3A and H3F3B mutations in a multicenter cohort of CB patients.

Forty-three patients with histopathologically confirmed CB were included in a retrospective analysis. All cases were re-evaluated by 2 pathologists, and mutation analysis of H3F3A and H3F3B genes was performed using polymerase chain reaction-based Sanger sequencing.

H3F3B mutations were detected in 41 cases (95.3%), all corresponding to the Lys36Met substitution. One case (2.3%) harbored an H3F3A Gly34Trp mutation, whereas 1 case (2.3%) showed no detectable mutation. No significant histopathological differences were observed between mutation-positive and mutation-negative cases. A notable case involved a 72-year-old patient with frontal bone involvement, highlighting the diagnostic difficulty in unusual locations and older age groups.

The findings demonstrate that H3F3B mutation analysis is an extremely sensitive and reliable molecular tool for confirming the diagnosis of CB. It is particularly valuable in challenging cases and especially in small biopsy samples where pathognomonic findings, such as chicken-wire calcification and chondroid matrix are not visible. Incorporation of molecular testing into targeted diagnostic workflows may improve diagnostic accuracy and assist in distinguishing CB from its histological mimics.   Cite this article as: Tosun I, Yilmaz I, Cakir A, et al. H3F3B gene mutation in chondroblastomas: a multicenter study. Acta Orthop Traumatol Turc.,2026; 60(4), 0277, doi: 10.5152/j.aott.2026.25277.