Ferroptosis is a regulated form of cell death in which disturbed iron metabolism, accumulation of peroxidized membrane lipids, and insufficient glutathione peroxidase 4 (GPX4) activity converge to injure vascular cells. In atherosclerosis, its effects are highly dependent on cellular context rather than being uniform across the vessel wall. In macrophages, ferroptotic injury strengthens inflammatory signaling and contributes to necrotic-core growth; in vascular smooth muscle cells, it impairs mitochondrial fitness, contractile phenotype maintenance, and extracellular matrix support, thereby weakening the fibrous cap; and in endothelial cells, it disrupts redox homeostasis and barrier function, facilitating lipid entry and early lesion formation. This review synthesizes recent advances in the molecular regulation of ferroptosis in atherosclerosis and emphasizes how its functional consequences differ among plaque-resident cell types. We also discuss natural products and traditional Chinese medicine-derived compounds as promising modulators of ferroptosis-related pathways, owing to their multi-target actions and potential suitability for chronic vascular intervention. By connecting mechanistic evidence with therapeutic implications, we propose that cell-type-aware regulation of ferroptosis, rather than indiscriminate suppression, may offer a rational strategy for plaque stabilization and cardiovascular risk reduction. Significance: Ferroptosis is increasingly recognized as an important contributor to atherosclerosis, but its vascular effects vary substantially among endothelial cells, macrophages, and vascular smooth muscle cells. This review analyzes how cell-specific differences in iron handling, lipid peroxidation, and antioxidant defenses shape plaque initiation, inflammatory progression, and fibrous-cap stability. We further summarize evidence that natural compounds can modulate these ferroptosis-related networks and restore redox and cellular homeostasis. By linking vascular cell heterogeneity with natural product-based intervention strategies, this review provides a mechanistic and translational framework for more precise targeting of ferroptosis in atherosclerosis.

Financial strain is associated with suicide risk; however, no research has examined financial stressors in the year preceding suicide using national credit data.

To assess financial stressors in the 12 months preceding suicide in a national sample of veterans by linking financial, mortality, and health care records.

This case-control study of 5000 veterans who died by suicide (January 1, 2015 to December 31, 2017) used mortality data from the US Department of Veterans Affairs (VA) and the US Department of Defense. Cases were matched to 12 500 living controls on age, sex, VA health care use, and suicide index date. Analyses were conducted in December 2025.

Financial stressors in the prior 12 months were identified in TransUnion credit records provided by FinThrive.

The primary outcome was death by suicide. Differences between cases and controls were analyzed using multivariable conditional logistic regression, adjusting for demographics and, among VA users, marital status and diagnoses of depression, posttraumatic stress disorder, and substance use disorder.

Among 17 439 veterans included in this study, the mean (SD) age was 52.9 (15.7) years, and 94.6% were male. Suicide was associated with having (vs not having) delinquent mortgage payments (odds ratio [OR], 1.4; 95% CI, 1.2-1.7), repossessions (OR, 1.9; 95% CI, 1.3-2.7), and credit card payments 30 or more days past due (OR, 1.7; 95% CI, 1.6-1.9). Lower credit score categories were associated with increasing odds of suicide. Veterans with 3 or more financial stressors had higher odds of suicide (OR, 2.4; 95% CI, 1.9-3.0) compared with those who had none. Among individuals with available data, credit score declines of 51 to 100 points (OR, 1.3; 95% CI, 1.1-1.5) and greater than 100 points (OR, 2.8; 95% CI, 2.3-3.5) over 1 year, relative to no change in score, were associated with increased odds of suicide. Cumulative financial stressors and declining credit scores had the highest ORs for suicide when adjusting for demographics and, among VA users, marital status and prior psychiatric diagnoses. ORs were lower among VA users than among non-VA users.

In this case-control study, suicide was associated with financial stressors in the prior 12 months. Incorporating financial stressors into clinical evaluations and safety planning may aid in identifying patients at risk for suicide. Policymakers and researchers could consider strategies to detect and mitigate financial stressors as part of comprehensive suicide prevention efforts.

Sexual and gender minoritized adolescents (SGMA) are at higher risk for self-injurious thoughts and behaviors (STB), such as suicide and nonsuicidal self-injury, compared to their heterosexual and cisgender peers. This study explored treatment experiences, barriers, and facilitators to treatment for SGMA at risk for STB. Participants were 18 SGMA, aged 13-19 years (M = 16.8; SD = 1.89); 61% were transgender or nonbinary; 61% plurisexual; and 78% White, non-Hispanic/Latine. Participants completed a semistructured interview, including questions about their experiences seeking mental health treatment for STB. Several themes emerged for negative treatment experiences (e.g., overemphasis on identity, invalidation), positive treatment experiences (e.g., affirmative work), barriers to treatment (e.g., shame, structural barriers), facilitators to treatment (e.g., family support), and recommendations to mental health professionals. The findings of this study provide insights into the varied STB treatment experiences of SGMA at risk for STB. These results underscore the importance of SGM-affirmative clinical practice and have significant implications for research and clinical interventions for SGMA. Additionally, our findings provide useful recommendations from SGMA to help guide mental health professionals in developing SGM-affirmative interventions. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

Health care staff work in high-stress environments that increase risk for mental health challenges; however, racial/ethnic minority staff may be less likely to access care. Understanding mental health service utilization patterns and barriers among diverse health care staff is essential for developing culturally responsive interventions. An anonymous cross-sectional survey was distributed to health care staff at a large urban hospital (September to October 2022). The survey assessed demographics, occupational stressors, mental health symptoms, service utilization, and perceived barriers to care. Descriptive and bivariate analyses examined differences by race/ethnicity, and multinomial logistic regression identified correlates of perceived need and service utilization. Of 4,998 invited staff, survey responses were available for 1,119 (22.4%) participants, and 811 were included in regression analyses. Participants identified as White (28.2%), Asian (24.2%), Hispanic (24.8%), and Black (22.8%); most were women (84%) and ages 20-39 (52.3%). Asian, Black, and Hispanic staff were more likely to report no perceived need for mental health services compared with White staff. Service utilization was highest among White participants (26.4%) and lowest among Asian participants (14.9%). Across all racial and ethnic groups, the most frequently endorsed barriers were related to behavioral intention to seek services, knowledge, and inconvenient timing. Racial and ethnic minority health care staff reported lower mental health service utilization despite similar workplace stressors. The lower perceived need among minority staff suggests that access-focused interventions alone may be insufficient. Efforts to improve equity should address both access barriers and factors influencing perceived need. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

RSV infections in children affect the entire family. Nevertheless, evidence on the overall impact is scarce. This multi-country observational study aims to investigate the association between disease severity and health-related quality of life (HRQoL) in affected families and to explore the role of factors related to mental well-being.

Data were collected during the 2022-2023 RSV season in Germany, France, Italy and Sweden via an online questionnaire from parents of children (24 months) hospitalised for RSV. Parental HRQoL was assessed using the validated caregiver-reported PedsQL Family Impact Module. Exploratory analyses and multivariate linear regression models were performed focusing on potential key determinants.

A total set of 138 participants was assembled. Parents of children with a severe RSV infection had on average - 12.1 [95% CI: -21.2 to - 3.03; P = 0.010] lower HRQoL Summary Score than parents of children with low severity index scores. Subsequent stratified analyses revealed a stronger association among parents who had not been offered (adequate) mental health support.

Higher RSV disease severity was associated with lower parental HRQoL. These findings highlight the importance of preventing severe RSV infection and the need for further research to identify and evaluate appropriate (psychosocial) support for affected families.

ClinicalTrials.gov, identifier, NCT05550545. Registered 12 September 2022.

Suicidal ideation and behavior during the postpartum period are increasingly recognized as important contributors to maternal morbidity and mortality, particularly in high-income countries. Although postpartum depression is a well-established risk factor, emerging evidence suggests that suicidality may also occur independently and therefore remain underrecognized in clinical practice. This systematic review aimed to synthesize current evidence regarding the prevalence of suicidal ideation and behavior in the postpartum period and to identify associated risk factors.

A systematic search of PubMed, Web of Science, EMBASE, and PsycINFO was conducted up to March 2025 following PRISMA guidelines. Twenty studies met inclusion criteria, encompassing 352,726 postpartum women across diverse international settings. Reported prevalence of suicidal ideation ranged from 2.2% to over 50%, depending on the population studied and assessment methods used. The most frequently identified risk factors included postpartum depression, anxiety, trauma history, intimate partner violence, unplanned pregnancy, low socioeconomic status, low social support, and adverse childhood experiences. Notably, several studies reported suicidal ideation even in the absence of clinical depression. Only a limited number of studies addressed preventive interventions. Postpartum suicidality appears to be a multifactorial phenomenon that cannot be explained solely by depressive symptomatology. The findings highlight the need for broader screening strategies that incorporate psychosocial and trauma-related factors in addition to depression. Integrated and trauma-informed approaches to screening and prevention may improve early identification of at-risk individuals. Future research should prioritize longitudinal designs and culturally sensitive investigations to better inform prevention and intervention strategies.

The January 2025 wildfires in Los Angeles County (LAC) caused widespread destruction and disproportionately affected linguistically diverse communities. Chinese immigrants, one of the largest immigrant groups in LAC, may have experienced heightened vulnerability due to limited English proficiency. To examine Chinese immigrants' experiences with emergency alerts and recovery during the 2025 wildfire, we conducted two focus groups in January 2026 with 16 Chinese participants who had been directly impacted by the wildfire. Discussions explored their trusted communication channels, fire alerts, evacuation experiences, recovery processes, mental health impacts, and suggestions. Participants relied on diverse information sources, including Google, social media, newspapers, TV/radio, and personal networks, to obtain updates during the wildfires. Delayed notifications, inconsistent geographic coverage, language barriers, and technical disruptions limited timely access to fire warnings. Evacuation guidance often lacked actionable details, and older adults faced heightened vulnerability due to mobility limitations, digital literacy barriers, and inadequate evacuation protocols in senior housing settings. Post-disaster recovery was complicated by bureaucratic complexity, adversarial insurance processes, environmental health concerns, and limited multilingual support. Persistent psychological distress was common, yet access to culturally appropriate mental health services was limited. Participants called for an integrated information system hosted by trusted community organizations. Disaster preparedness systems must extend beyond translation to develop culturally responsive, age-inclusive, and community-partnered approaches. Strengthening multilingual alert systems, senior-specific evacuation planning, centralized navigation support, and culturally integrated mental health services may improve preparedness and recovery for immigrant communities facing increasing climate-related disasters.

Family caregivers in East Asian societies such as Hong Kong bear a significant share of care responsibilities for individuals with disabilities due to rising disability prevalence, limited formal services, and cultural norms rooted in filial piety. This study examines factors associated with caregiving provision, weekly caregiving hours, and mental stress among family caregivers in Hong Kong households. We used data from the 2019-2020 Hong Kong General Household Survey (n = 40,600) and applied logistic regression (caregiving provision) and ordinal logistic regression (caregiving hours, mental stress). Analyses were adjusted for care recipient needs, caregiver characteristics, and contextual factors. Disability types were classified using the International Classification of Functioning, Disability and Health (ICF) framework. Among weighted respondents from households including individuals with disabilities in Hong Kong, 14.5% were identified as family caregivers. Caregiving was significantly associated with being female (adjusted odds ratio [aOR] = 1.64, 95% CI = 1.49-1.82) and unmarried (aOR = 1.17, 95% CI = 1.02-1.34). Female (aOR = 1.33, 95% CI = 1.12-1.59) and assisting with activities of daily living (ADLs) were associated with longer weekly caregiving hours (aOR = 2.54, 95% CI = 2.12-3.04). Severe self-reported mental stress was associated with female (aOR = 1.39, 95% CI = 1.15-1.69), assisting with ADLs (aOR = 1.99, 95% CI = 1.62-2.44), and caring for family members with mental health disability (aOR = 2.00, 95% CI = 1.64-2.43). While other ICF-based disability types were not significant in multivariate models, some showed associations in univariate analysis. These findings highlight the need for targeted caregiver support policies that address gendered expectations and disability-specific burdens.

We aimed to evaluate the level of implementation of health care professionals in helping patients undergoing surgery quit smoking using the Ask, Advise, Assess, Assist, and Arrange Follow-Up (5As) brief intervention model, and to identify the main barriers and facilitators affecting the implementation during preoperative visits at hospitals in Catalonia, Spain.

In a multicentre cross-sectional study, we administed an online survey to clinical health care professionals who perform preoperative visits (anesthesiologists, nurses, and psychologists). The main outcome variable was the implementation of 5As. We used the validated Knowledge, Attitudes, Behaviours, and Organization (KABO) questionnaire to assess barriers and facilitators. We performed univariate and bivariate analyses of the 5As and the KABO domains according to professional category and sociodemographic variables. We conducted multivariable analyses using generalized estimating equations controlling for covariates.

The survey was completed by 216 professionals of 633 invited to participate (34.1%). Engagement was high in the categories Ask (median [interquartile range] 0-10 Likert scale score, 10.0 [9.0-10.0]) and Advise (7.5 [5.0-10.0]), but very low in Assist (1.0 [0.0-3.0]) and Arrange Follow-Up (0.0 [0.0-2.0]). "Individual skills" and "organizational support/resources" had significantly lower scores compared with other domains (Holm-adjusted P < 0.05), whereas "Individual commitment" and "Beliefs about patients' desire/readiness" had significantly higher scores.

The level of implementation of smoking cessation in preoperative visits was poor. The main barriers detected were lack of knowledge and lack of resources and organizational support. Hospitals should promote strategies that address the main barriers identified and should apply interventions to help people quit smoking as a routine practice in preoperative visits.

Antidepressant use is common in people with dementia, and many start around the time of diagnosis. We hypothesised that those who commenced antidepressants at dementia diagnosis started for dementia-related symptoms, distinct from those with longstanding prescriptions, resulting in different characteristics in electronic records.

We carried out a retrospective cohort study using linked primary care (Lambeth DataNet) and mental health (Clinical Record Interactive Search) data for patients with dementia in south London, UK in 2009-22. Antidepressant prescription starting within one year before or after dementia diagnosis identified as 'new'. Dementia and anxiety were described using coded fields, a rating scale for neuropsychiatric symptoms and natural language processing of full-text.

Of 3713 patients with dementia, 28% were prescribed an antidepressant in the year of dementia diagnosis. 42% of these were 'new' prescriptions. Compared to the no antidepressant group, 'new' starters were more likely to be female (odds ratio (OR) 1.33, 95% 1.08-1.64) and have vascular dementia (OR 1.44, 1.13-1.83). Compared to longstanding antidepressant group, 'new' had similar depression and anxiety symptoms, but fewer coded mentions (OR 0.50, 0.39-0.65), especially those 'new' from non-White ethnicities. Deprescribing was equally unlikely in 'new' and longstanding (6.3% vs 5.5% per year of follow-up).

There is a high prevalence and lack of deprescribing, despite guidelines cautioning antidepressants. This points to unmet needs at the threshold of dementia. Clinicians should ensure good documentation of indication for antidepressants and proactive medication reviews for people with dementia.