Mental health concerns among individuals working in technology-driven occupational settings have emerged as a major workplace challenge. Persistent cognitive demands, prolonged screen exposure, sedentary work patterns, and psychosocial stressors are associated with burnout, sleep disturbance, emotional dysregulation, and reduced resilience. Emerging evidence suggests that yoga therapy (YT) may represent a promising mind-body approach for supporting stress regulation and psychophysiological balance in cognitively demanding work environments. This qualitative systematic review and thematic synthesis examined mechanistic and applied evidence related to yoga-based interventions in technology-related and comparable workplace populations. Literature searches were conducted across PubMed, Scopus, and Google Scholar (2010-2025). Eligible studies included randomized controlled trials, workplace intervention studies, mechanistic physiological investigations, observational studies, and relevant systematic reviews examining outcomes related to stress, autonomic function, emotional well-being, cognitive performance, and occupational health. Due to substantial heterogeneity across study designs, interventions, and outcome measures, findings were synthesized qualitatively. The included evidence suggests that YT may support autonomic regulation, heart rate variability modulation, and stress adaptation. Workplace-based interventions were generally associated with favorable trends in perceived stress reduction, sleep quality, emotional well-being, cognitive functioning, and occupational satisfaction. Brief yoga-based micro-practices also appeared feasible for workplace stress management and attentional recovery. Classical yogic concepts, including sattva and prāṇa vāta regulation, provide an interpretive framework for understanding the multidimensional effects of YT. Overall, yoga-based interventions may represent a promising integrative strategy for resilience-related outcomes in technology-driven occupational settings. However, findings should be interpreted cautiously because of methodological heterogeneity and limited occupation-specific evidence. This review was prospectively registered with PROSPERO (CRD420251240676).

Parent education is widespread and institutionalized in family courts across the USA, reflecting decades of research showing that children are at heightened risk for mental health and related problems following parental separation and divorce. Given their reach and scale, these programs represent one of the largest yet underutilized opportunities for prevention in the country. To bridge the gap between prevention science and court practice, we formed a research-practice partnership between the New York State Parent Education and Awareness Program (PEAP) and university prevention scientists to co-develop and implement a statewide randomized controlled trial testing two online parent education programs (eNew Beginnings Program and PEACE). Launched in May 2025 across 16 courts, the trial embeds a randomized comparison of two programs within existing judicial referral procedures using centralized enrollment, voluntary participation with a business-as-usual alternative, and a jurisdiction-specific base module that was designed to ensure compliance with statewide parent education. Early implementation data (reach, enrollment, and reasons for nonparticipation) provide preliminary evidence of feasibility of embedding prevention research within a statewide judicial system. This partnership will produce both rigorous evaluation data and implementation insights to inform the ongoing development, equitable implementation, and scale-up of evidence-based parent education.

With the rising prominence of GLP-1 receptor agonists, identifying predictors of optimal bariatric surgery candidates has become increasingly important. We investigated cross-sectional relationships between thyroid hormones and obesity-related parameters, and evaluated the predictive value of baseline thyroid hormones for weight loss (WL) and diabetes remission (DR) after bariatric surgery.

This study included a cross-sectional cohort of 1567 euthyroid patients with overweight or obesity, of whom 1034 with complete 1 year postoperative data were included in the longitudinal analysis. Body composition was assessed using validated predictive equations and abdominal MRI. The primary outcomes were successful WL (total WL ≥ 25%) and DR (fasting glucose < 5.6 mmol/L and HbA1c < 6.0% without antidiabetic medications) during the 3 year follow-up.

Breakpoint analysis indicated that free triiodothyronine (FT3) plateaued beyond an age threshold while showing a linear correlation with fat-free mass index. Higher baseline FT3 tertiles were significantly linked to increased likelihood of achieving successful WL and DR at 1 year follow-up, with stronger associations in females. Optimal FT3 thresholds were identified as 4.75 (females) and 5.05 (males) for WL, and 4.57 (females) and 5.00 (males) for DR. Preoperative FT3 levels below these thresholds were significantly associated with reduced WL and DR over 3 years.

Serum FT3 exhibits an age-related breakpoint effect, and low preoperative FT3, particularly in females, is a critical predictor of suboptimal short- and long-term WL and DR success post-bariatric surgery. Sex-specific FT3 thresholds may aid in preoperative risk stratification and inform personalised treatment decisions in the era of expanding obesity therapeutics.

Physical inactivity, sedentary behaviour and inadequate sleep are established risk factors for non-communicable diseases. Although older adults are traditionally expected to be less active and more sedentary than young adults, contemporary social, occupational and educational environments may have changed this. Here, we characterised 24-hour movement behaviours (physical activity [PA], sedentary behaviour [SB], and sleep) across adulthood using wearable devices and examined their cardiometabolic correlates using a compositional data approach.

Data were analysed from 1,967 adults across three Singaporean cohorts: university students (n = 500; mean[SD] age 19.9[1.3] years), working-age adults (n = 437; 41.1[10.0] years), and community-dwelling older adults (n = 1,030; 74.0[2.6] years). Each person contributed 4 weeks of Oura Ring recordings on time spent in PA, SB and sleep. BMI, body roundness index (BRI), pulse wave velocity (PWV), and a composite vascular health score (zComposite) were additionally assessed. Associations between reallocations of time across 24 h-movement behaviours and these cardiometabolic outcomes were estimated using compositional data regression models.

University students accumulated the most SB (mean 633.89 min/day) and the lowest PA (320.28 min/day) and sleep (431.75 min/day), whereas older adults accumulated the least SB (500.86 min/day) and greatest PA (420.28 min/day) and sleep (455.62 min/day). Working-age adults showed profiles in-between the students and older adults (SB: 581.28 min/day; PA: 346.55 min/day; sleep: 445.77 min/day). In compositional models, reallocating 30 min per day to PA from other behaviours was associated with lower BMI (-0.13 kg/m²), BRI (-0.04), PWV (-0.05 m/s), and zComposite (-0.01). Reallocating 30 min per day from SB to other behaviours was associated with lower BMI (-0.28 kg/m²) and BRI (-0.07). Reallocating 30 min per day to sleep from other behaviours was related to lower BMI (-0.21 kg/m²) and BRI (-0.05).

University students exhibited lower physical activity and higher sedentary time than older adults. Reallocation of time toward greater PA, less SB and longer sleep was associated with lower cardiometabolic risk. These findings challenge conventional expectations about age-related inactivity and highlight young adulthood as a critical, under-recognised target for interventions to promote PA and reduce SB for long-term health.

Oral diseases are among the most prevalent non-communicable conditions worldwide, contributing to significant health burdens and disparities. In response, the World Health Organization established the Global Oral Health Action Plan 2023-2030, urging countries to integrate oral health into universal health coverage and adopt comprehensive prevention strategies. This article examines Israel's alignment with these objectives.

Over the past 15 years, Israel has advanced oral health within Universal Health Coverage by integrating dental services into the National Health Insurance Law and progressively expanding public financing to children and the elderly, while maintaining coverage for special patient groups. Children and the elderly now account for over 40% of those eligible for publicly funded dental care. Prevention is central to policy. National school and mother-and-child health programs provide supervised toothbrushing, fluoride varnish applications, and oral health education, reaching nearly all children in recognized educational settings. Multidisciplinary primary care models link dental professionals with nurses and pediatric providers to deliver coordinated, life-course services, while strengthening the oral health workforce. Additional system measures include front-of-pack sugar warning labels, a national policy to phase down dental amalgam use, and ongoing efforts to establish a unified digital surveillance system for oral health. Together, expanded coverage, prevention-focused delivery, workforce development, and system strengthening position oral health as an integral component of Universal Health Coverage in Israel.

Israel has made considerable progress in aligning with the Global Oral Health Action Plan, particularly by expanding coverage and preventive interventions for children and the elderly. However, continued efforts are needed to address remaining gaps in adult coverage, strengthen the capacity and distribution of the oral health workforce, and further integrate oral health care into innovative, multidisciplinary models. Systematic surveillance systems are also needed to accurately track disease burden and ensure equitable outcomes across all population groups.

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver condition characterized by excessive fat accumulation in hepatocytes, affecting individuals globally. With a prevalence of 32% among adults, NAFLD is linked to obesity, metabolic disorders, and type 2 diabetes mellitus (T2DM), yet awareness remains disproportionately low, reaching as low as 4.4% in some developed countries like the US, despite its high prevalence. In Saudi Arabia, specifically the Makkah region, data regarding public awareness are scarce. This study aims to bridge this gap by assessing NAFLD awareness and its predictors among Makkah residents.

A cross-sectional study was conducted using an electronic questionnaire (Google Forms) distributed through social media platforms, with 716 participants (aged ≥18 years) included, who are adult residents of Makkah, Saudi Arabia. The questionnaire gathered demographic information and assessed NAFLD knowledge. The survey instrument was self-constructed; while formal psychometric validation was not conducted, content validity was ensured through review by academic faculty experts. Data were analyzed using RStudio (version 4.3.1). Descriptive statistics, Pearson's chi-square, and Fisher's exact tests were utilized. Multivariable logistic regression was performed to identify significant predictors of awareness, with results reported as odds ratios (ORs) and 95% confidence intervals (CIs).

Of the 716 participants, 80% were female, and 54.1% were aged 18-25 years. Only 30.3% were aware of NAFLD, primarily through the Internet (59.9%). Awareness of symptoms was critically low (17.9%). Significant predictors included higher education (p = 0.010) and older age (p = 0.038). Notably, participants with a family history of NAFLD were 32.7 times more likely to be aware of the condition (OR = 32.7, p < 0.001).

The study reveals significant gaps in NAFLD awareness and knowledge among Makkah residents. Given that the internet is the leading source of information, we recommend launching interactive social media campaigns led by trusted healthcare professionals to provide simplified, evidence-based content. In addition, increasing local research and conducting awareness days in public places are essential steps. These practical actions will bridge the knowledge gap, support early detection, and help prevent serious liver complications.

Submandibular abscesses, a type of polymicrobial deep neck infection (DNI), are an otolaryngologic emergency due to the risk of airway compromise and septic shock. Unilateral submandibular abscesses are common and are often the result of odontogenic infections, while comorbidities that weaken the immune system, such as diabetes mellitus or human immunodeficiency virus (HIV), can exacerbate the infection. Bilateral submandibular abscesses are rare with limited cases reported in the literature, and are often associated with severe or systemic infections. This case report highlights the importance of a thorough physical examination and rapid intervention when evaluating a patient with suspected sepsis, presenting with nonspecific symptoms in the setting of multiple comorbidities. Rapid identification and appropriate management of a DNI such as bilateral submandibular abscesses is critical to preventing deterioration, including progression to sepsis, osteomyelitis, airway compromise, and death.

Gallstone disease constitutes a substantial global health burden, characterized by notable clinical heterogeneity and a complex risk of recurrence. However, large-scale studies systematically characterizing this heterogeneity and translating these findings into clinically applicable prediction tools remain limited. This study sought to systematically elucidate the clinical heterogeneity within a large cohort of gallstone patients, identify independent risk factors for postoperative recurrence, and develop a machine learning-based model for postoperative recurrence prediction.

We conducted a retrospective analysis of 9,939 patients undergoing gallstone surgery between January 2017 and December 2023 at the Third Hospital of Shandong Province. Clinical data, including demographics, gallstone type, size, comorbidities, and recurrence status, were extracted. Statistical analyses compared subgroups based on sex, age, stone type, complication status, and recurrence. Age- and sex-matched non-recurrence controls were selected in a 1:1 case-control design. Independent recurrence-associated factors were identified using univariate and multivariable logistic regression analyses. A Random Forest model was subsequently constructed using routinely available clinical variables and evaluated in independent training and testing datasets.

Marked clinical heterogeneity was observed across sex, age groups, stone locations, and recurrence status. Distinct associations were identified between specific stone distributions and comorbidity patterns. Multivariable logistic regression identified stone size, diabetes mellitus, venous thrombosis, liver cirrhosis, and malignant tumors as independent factors associated with recurrence. The Random Forest prediction model, incorporating these factors along with sex and age, demonstrated excellent performance with an area under the curve (AUC) of 0.873 on the test set. Variable importance analysis highlighted stone size and cirrhosis as the most influential predictors.

Gallstone disease is characterized by substantial clinical heterogeneity. The identified recurrence-associated factors and machine learning model provide a potential framework for individualized recurrence risk assessment and may facilitate postoperative management following further external and prospective validation.

 Diabetic kidney disease (DKD) is characterized by chronic inflammation and progressive protein-energy wasting. The Prognostic Nutritional Index (PNI) represents a promising marker for assessing immunonutritional deterioration. Our study aims to evaluate the PNI in patients with type 1 (T1D) and type 2 (T2D) diabetes mellitus with chronic kidney disease (CKD) across all its stages.

 A retrospective, cross-sectional analytical study was conducted among patients aged >18 years with T1DM and T2DM, followed between January 2025 and January 2026 at the Department of Endocrinology, Diabetology, and Metabolic Diseases, Hassan II University Hospital, Fez, Morocco. DKD was defined as an albumin-to-creatinine ratio (ACR) >30 mg/g and/or an estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m² for ≥3 months. The PNI was calculated using the equation: [Formula: see text], with PNI ≥50 as normal nutritional status. We stratified patients into three groups: G1: ACR between 30 and 300 mg/g and/or eGFR between 60 and 90 mL/min/1.73 m²; G2: ACR >300 mg/g and/or eGFR <60 mL/min/1.73 m² (moderate-to-advanced DKD); G3: eGFR <30 mL/min/1.73 m² regardless of ACR (severe DKD). Exclusion criteria included incomplete medical records, active infection, cirrhosis, cancer, nephrotic syndrome, and chronic inflammatory conditions. Multivariate linear regression was adjusted for demographic factors, diabetes duration, and glycated hemoglobin (HbA1c). Statistical analyses were performed using IBM SPSS Statistics for Windows, Version 26 (Released 2018; IBM Corp., Armonk, New York, United States), with p < 0.05 considered statistically significant.

Seventy-eight patients were included (41 T2DM and 37 T1DM). Mean age was 47.3 ± 11.4 years, with female predominance (male-to-female ratio: 0.41). Mean diabetes duration was 23 ± 7.3 years, and mean HbA1c was 11%. Mean PNI was 42.8 in G1 (n = 41), 35.6 in G2 (n = 21), and 28.1 in G3 (n = 16). Multivariate analysis showed a significant deterioration of immunonutritional markers with DKD progression (p < 0.05), with T1DM patients showing more marked kidney function worsening. PNI correlated positively with eGFR (p = 0.002) and inversely with ACR (p = 0.043). In linear regression, eGFR was independently associated with PNI (p = 0.002), and advanced nephropathy stage emerged as the strongest independent predictor of PNI decline (β = -6.47, 95% CI: -11.29 to -1.65, p = 0.011).

 Immunonutritional status deteriorates progressively with the advancement of DKD. These findings suggest that PNI may represent a useful adjunctive marker of DKD to better identify patients at risk of protein-energy wasting and adverse outcomes.

Melioidosis is a potentially fatal endemic infection caused by the Gram-negative bacterium Burkholderia pseudomallei. The disease may present with a wide spectrum of clinical manifestations, including pneumonia, visceral abscesses, and septicemia. Neurological complications are uncommon but have been reported, with dural venous sinus thrombosis being a particularly rare manifestation. We describe a case of a 55-year-old Malay woman with underlying diabetes mellitus and hypertension who presented with a one-week history of fever, confusion, back pain, and dyspnoea. Blood cultures grew Burkholderia pseudomallei, and imaging demonstrated disseminated infection with multiple splenic abscesses and pulmonary septic emboli, as well as dural venous sinus thrombosis. The patient was initially treated with intravenous meropenem, followed by ceftazidime and oral trimethoprim-sulfamethoxazole as part of eradication therapy. Therapeutic anticoagulation with enoxaparin was also initiated. Follow-up imaging demonstrated significant resolution of the visceral abscesses and pulmonary lesions.