Alzheimer's disease (AD) research relies on large datasets and advanced statistical models. However, individual population studies often lack sufficient sample size for conclusive results. Harmonizing cognitive test data across studies can address this gap, despite differences in testing protocols. This study harmonizes cognitive data from three major AD cohorts to support robust clinical-pathological modelling.

Information from the Alzheimer's Disease Neuroimaging Initiative (N = 1446); Australian Imaging, Biomarkers and Lifestyle (N = 1764); and Open Access Series of Imaging Studies-3 (N = 440) were integrated, including cognitive scores, demographics, genetics, and clinical and neuroimaging data. Neuropsychological tests relevant to AD were harmonized using MissForest, a machine learning-based imputation method. Validation involved assessing imputation accuracy and analyzing composite cognitive scores across clinical-pathological groups.

Imputation showed high accuracy (mean absolute error ≤ test-retest variability in cognitively unimpaired participants). Composite scores reflected known disease patterns with significant stratification across clinical-pathological groups.

The validated harmonization approach demonstrated reliable imputation, enabling more powerful AD models and supporting future diagnostic and therapeutic advances.

No study has synthesized qualitative insights related to yoga across various women's health concerns, including breast and ovarian cancer, endometriosis, menopause, and pregnancy, despite numerous individual studies. The present review therefore sought to synthesize qualitative research on yoga, exploring participants' perceived psychological and physical effects and motivators for engagement in a therapeutic setting. PubMed, CINAHL, Embase, PsycInfo, SPORTDiscus, and Google Scholar were searched systematically for qualitative and mixed-methods (extracted qualitative only) designs. Data extraction, critical appraisal, and quality assessment followed the Joanna Briggs Institute (JBI) methodology for qualitative systematic reviews. Synthesis involved a phenomenological approach through thematic synthesis and meta-aggregation. Of 1,896 identified studies, 12 were included in the systematic review. Women aged 22-84 participated in various in-person yoga interventions spanning community yoga studios, community health centers, hospitals, and antenatal clinics, with data mainly collected through interviews, questionnaires, and surveys. Meta-aggregation yielded five secondary subthemes on participants' perceptions: (1) Fostering Community, Relationships, and Safe Spaces; (2) Emotional Balance, Self-Discovery, and Lifelong Learning; (3) Pain Relief and Physical Wellness; (4) Easing Stress and Anxiety Through Mindful Practice; and (5) The Journey to Confidence and Empowerment. We identified two secondary subthemes for motivations for engagement in yoga practice: (1) Desire to Heal Mentally and Physically; and (2) A Sense of Commitment and Community. Yoga positively affected mental and physical well-being, with participation motivators suggesting its potential as a complementary practice in women's health and life transitions.

With growing need to mitigate the mental health crisis on university campuses, researchers worldwide are seeking to determine effective student mental health promotion strategies, such as positive education (i.e., the teaching of applied positive psychology) and yoga. Nevertheless, a paucity of research appraises the effects of merging positive education and yoga for mental health. Therefore, the purpose of this study was to investigate the effect of a 6-week hatha yoga program on undergraduate positive education students' mental health, self-compassion, and vitality. In this mixed-methods single-case experimental A1BA2 design, 7 volunteer students enrolled in the positive education course completed a 2-week baseline (A1), followed by a 6-week yoga program that included two ≈ 45-minute weekly virtual yoga classes (B), and another 2-week baseline (A2; post-yoga), all while taking their positive education course. Trait variables (mental health, trait self-compassion, and trait subjective vitality) were assessed via validated questionnaires during the baseline phases preceding and following the yoga program, whereas state variables (state self-compassion and state subjective vitality) were assessed immediately before and after one of the weekly yoga sessions. Participants also responded to open-ended journal prompts related to the outcome variables following one of the sessions. Visual, stability, level, trend, and reflexive thematic analyses revealed that yoga practice was associated with improved trait and state well-being outcomes. This research suggests preliminary evidence for yoga and positive education courses as a means of increasing university students' mental health, self-compassion, and vitality both immediately and over time. Suggestions for yoga program implementation and future research are discussed.

This qualitative study explored the perceived expectations, benefits, and challenges of a 12-week community mindfulness-based yoga program for U.S. military veterans with PTSD symptoms. Although yoga has shown promise in reducing PTSD, depression, and anxiety symptoms among veterans, barriers to engagement persist, particularly concerning psychological perceptions of complementary and integrative health approaches. Our study builds on prior feasibility research by assessing veterans' subjective experiences through a focus group conducted after program completion. Twelve veterans were recruited for the intervention, with six participating in the focus group. Upon intervention completion, participants were asked about their perceptions of the program, including benefits and challenges, in addition to ability to cope with physiological PTSD symptoms. Thematic content analysis of the focus group transcripts revealed that the group exhibited initial apprehension, particularly centered around whether yoga was an appropriate form of exercise for veterans given stereotypes related to the practice. Nevertheless, participants described feelings of empowerment and increased self-efficacy upon leaving the program. Endorsed challenges included anxiety and avoidance, which served as barriers to attending. Participants did not explicitly report gaining control over physiological PTSD symptoms; rather, they emphasized that the program helped them overcome mental barriers and fostered acceptance rather than rigid control. Throughout, the program was identified as filling an unmet need for the veteran community. Findings suggest that veterans perceive a unique utility of community-based yoga programs. Specifically, the intervention promoted engagement in self-care, which, in turn, may help the ability to cope with PTSD symptoms.

Cyberbullying and school bullying among adolescents continues to increase, and is associated with academic difficulties, isolation, anxiety, and depression, and in severe cases, self-harming or suicidal thoughts and behaviors. Yet effects of bullying victimization on suicidality in American youth, especially differences by sex, race and orientation, remain largely unquantified.

We analyzed Youth Risk Behavior Surveillance System (YRBSS) data from U.S. high school students (N = 94,492), first examining temporal trends in suicidality by bullying exposure from 2011 to 2023, with attention to changes before and after the COVID-19 pandemic. We then examined adjusted associations between cyberbullying, bullying, and suicidality, assessing effect modification by sex, sexual orientation and race.

Both cyberbullying and school bullying were significantly associated with increased odds of suicidality. Temporal analysis shows a post-2020 peak in the associations. While females had higher overall suicidality, bullying showed stronger relative effects among males, challenging assumptions about gender vulnerability. Bullying was associated with suicidality across sexual orientation groups, with bisexual students exposed to cyberbullying showing the highest adjusted odds, echoing research on sexual minority youth mental health disparities. Racial and ethnic subgroup analyses also indicated elevated risk among Indigenous and multiracial adolescents.

Cyberbullying is significantly associated with increased suicidality risk among adolescents, highlighting the need for targeted support for vulnerable groups. Findings suggest two key dimensions of risk: persistent effects of bullying and population-level shifts in suicidality risk over time. Addressing both requires intersectional strategies to strengthen school climates and expand access to culturally and developmentally appropriate care.

Cardiac telerehabilitation (tele-CR) uses home-based or hybrid delivery to provide multidisciplinary cardiac rehabilitation reducing travel and time barriers. However, tele-CR outcomes may be influenced by engagement, therapeutic relationships, and contextual and implementation constraints. This narrative review synthesizes evidence on psychological, social, and implementation factors that optimize tele-CR uptake, adherence, and effectiveness.

We conducted a targeted literature search in PubMed, Scopus, PsycINFO, and Embase (January 2021-January 2026). We included randomized and observational studies, qualitative and mixed-methods research, and systematic reviews/meta-analyses involving adults with cardiovascular disease participating in home-based, hybrid, or fully remote tele-CR. Reporting followed the Scale for the Assessment of Narrative Review Articles (SANRA).

Tele-CR is a sociotechnical, biopsychosocial intervention in which outcomes emerge from the integration of digital tools (monitoring, feedback, interfaces), clinical workflows, and patients' everyday contexts. Self-monitoring and structured feedback can strengthen self-efficacy and habit formation when data are interpretable and linked to actionable guidance. Remote delivery can reduce non-verbal cues, but continuity may improve through routine check-ins and responsive follow-up. An equity-by-design approach tailors delivery to connectivity, privacy, health literacy, language needs, and caregiver capacity. Across studies, feasibility and acceptability were associated with usability, support, and perceived value.

Tele-CR can broaden access to cardiac rehabilitation, but scalable benefit requires relationship-centred, equity-oriented service design. Priorities include calibrating monitoring to clinical actionability, reducing cognitive load through plain-language interfaces and structured onboarding, integrating routine mental health screening and patient-reported outcomes, supporting caregivers as end-users, and embedding implementation metrics and continuous quality improvement alongside clinical outcomes.

Environmental stress and iron deficiency are increasingly recognised as prevalent challenges during pregnancy, with significant implications for both maternal and foetal health. Environmental stressors such as chronic maternal anxiety can elevate cortisol levels and trigger inflammatory responses which might subsequently disrupt foetal brain development. Concurrently, iron deficiency during critical windows of gestation can hinder the formation of brain structures and neurotransmitter systems vital for emotional regulation and cognitive function after birth. Iron deficiency and exposure to stress are among the most prevalent nutritional and environmental challenges during pregnancy, and their combined influence may substantially increase the risk of neuropsychiatric disorders in the offspring. Although the individual effects of each factor are relatively well understood, their interaction during gestation remains unexplored.

In the present study, we employed human placental samples from mildly stressed and non-stressed mothers, a chronic environmental stress mouse model, and advanced in vitro techniques to examine whether gestational environmental stress alters placental iron transport.

Our findings indicate that stress enhanced placental iron uptake and accumulation, but paradoxically reduced iron transfer to the foetus-an effect observed exclusively in females and reproducible in vitro following both stress exposure and dexamethasone treatment.

These results provide insights into the sex-specific impact of environmental stress on placental and foetal iron availability and highlight a previously unrecognised pathway through which prenatal stress could influence long-term health trajectories in the offspring.

This study was supported by the Swiss National Science Foundation (SNF grant no. 310030_197408), the Swiss National Science Foundation via the National Center of Competence in Research (NCCR) TransCure, University of Bern, Switzerland (grant no. 51NF40_185544) and the Swiss 3R Competence Centre (3RCC; grant no OC-2019-019). TF was supported by the Hans Sigrist Foundation, Switzerland.

Although intimate partner violence (IPV) research has historically focused on female victimisation, emerging studies now examine heterosexual male victims. This qualitative systematic review synthesises evidence from five continents, including the underrepresented African context, to explore men's IPV experiences, coping strategies, psychological effects, and public health implications.

Systematic review of qualitative studies on male IPV victimisation, coping, and psychological well-being.

A systematic review of 36 qualitative studies was conducted, focusing on male IPV victimisation, coping strategies, and psychological outcomes. Inductive codes developed directly from participants' responses were used to identify experiences, coping strategies, and psychological outcomes. Related codes were then grouped into higher order concepts and mapped onto a problem focused versus emotion focused coping spectrum.

Findings reveal that male victims experience physical, psychological and sexual abuse, including broken bones, humiliation, and forced sexual intimacy. Coping strategies were both adaptive (e.g., exercise, spiritual coping) and maladaptive (e.g., alcohol use, avoidance, minimization or exiting the relationship). Emotion-focused strategies were more frequently associated with negative mental health outcomes. Problem-focused coping like help seeking had mixed psychological outcomes. Moreover, help-seeking was often hindered by stigma, fear of emasculation, and lack of awareness of available resources. Religious coping and informal support were mentioned but underexplored. The review also highlights the absence of theoretical framing and cultural sensitivity in many studies.

Public health systems should adopt gender-sensitive IPV responses, recognising male victimisation and reducing barriers to support. Further research should explore culturally relevant coping strategies and inform practitioner-led interventions.

In the context of cognitive neuroscience research on aging, older women are often overrepresented in observational research, whereas men are overrepresented in clinical trials. Factors underlying the selection bias between and across genders in research on aging are currently poorly understood. Addressing this knowledge gap is critical to provide guidance on how we might mitigate selection bias and improve the generalizability, robustness, and reproducibility of our findings. We aimed to identify the barriers and facilitating factors that older adults perceive when considering participation in cognitive neuroscience research that were shared across, or that differed between, older women and men. We employed fuzzy cognitive mapping (FCM), a method that facilitates participation in research and action. Maps were co-created individually with research participants to identify factors, and their inter-relationships, that encouraged or hindered their participation in research. These factors were then standardized across maps, categorized through thematic analysis, and organized into group-level causal networks using graph theory methods. Our results indicated that both older women and men perceived individual psychological motivators, the quality of communication with the research team, logistic considerations and research-specific practices as key factors that influenced their participation in research. Dissociable factors between genders were also identified: Prior personal and professional experiences facilitated research engagement in women, whereas willingness to return benefits to the general population encouraged men's research participation. These findings provide insights to guide the development of sampling strategies that enable equitable access to research and enhanced sample representativeness among women and men in research on aging.

Hikikomori is a phenomenon of social isolation characterized by an individual's intentional and prolonged withdrawal from social life, and it has increasingly drawn global scholarly attention. In Turkey, the limited number of empirical studies on hikikomori underscores the importance of examining its psychological determinants among young adults. This study aims to analyze the relationships between depression, psychological resilience, and hikikomori-related tendencies in individuals aged 18 to 34, and to test the mediating role of psychological resilience in these associations.

The study employed a quantitative, cross-sectional design and included 776 young adults recruited through convenience sampling. Participants completed the Beck Depression Inventory, the Brief Resilience Scale, and the Adaptive Behaviors Scale for Hikikomori Self-Report. Data were analyzed using SPSS 25.0, and mediation analysis was conducted using Pearson correlation and Hayes' PROCESS macro (Model 4).

Higher levels of depression were associated with an increase in hikikomori-related withdrawal behaviors, whereas higher levels of psychological resilience were related to more adaptive functioning. Psychological resilience significantly mediated the association between depression and hikikomori tendencies, indicating that depression influences social withdrawal partly through its impact on resilience.

The findings suggest that psychological resilience functions as a protective mechanism against social withdrawal among young adults. Strengthening resilience may therefore serve as an important target for preventive and therapeutic interventions. These results highlight the value of resilience-focused approaches within youth mental health policies and clinical practice.