Cyberbullying represents a severe public health issue, endangering the mental and physical health of adolescents. Externalizing problem behaviors are significant factors for cyberbullying perpetration. However, the spreading effects between them remain debated. This study applied network analyses to further examine the spreading effects. We focused on two subtypes of cyberbullying perpetration (cyber verbal aggression; cyber relational aggression) and five subtypes of externalizing problem behaviors (academic misbehaviors; vandalism behaviors; aggressive behaviors; interpersonal dishonesty behaviors; risk-taking behaviors). The valid sample consisted of 2075 Chinese adolescents who completed surveys at three time points, spaced 6 months apart. The contemporaneous and cross-lagged panel networks were constructed. Results suggest that the spreading effect is bidirectional over the 6-month interval, but unidirectional in the 12-month interval, and behavior subtypes play different roles. Among the five subtypes of externalizing problem behaviors, interpersonal dishonesty behaviors especially warrant consideration as a risk signal for cyberbullying perpetration, potentially serving as both a precursor and an outcome. These findings advance understandings of developmental cascades at the behavioral level by shifting focus from broad behavior categories to specific subtypes. Identifying such detailed behavioral risk signals enables earlier detection of and more targeted interventions against cyberbullying perpetration, ultimately contributing to protecting adolescents.

There has been an increase in interest in the health and well-being benefits of lifestyle factors such as physical activity, diet, sleep, and social interaction. Previous research has highlighted how lifestyle factors, both healthy and unhealthy, tend to covary or cluster together. Very little research has examined the degree to which the clustering among lifestyle factors and emotional health is unique to individuals. As such, this project examined the idiographic associations among lifestyle behaviors and emotional experiences in daily life, which could set the stage for individualized lifestyle interventions. Seventy-nine adults (M_age = 43.37, SD_age = 17.26) in the United States participated in a 70-day daily diary study, where they reported on daily lifestyle engagement and affect each evening. Network models examined the associations among these variables at the between-person level and within-person level. Further, person-specific idiographic network models were analyzed. Results indicate that there were significant associations in the whole sample at multiple levels (between-person and within-person). Further, idiographic analyses revealed person-specific connections among lifestyle factors and affect. In conclusion, lifestyle factors and affect cluster together in daily life, and the clustering differs across individuals. Future research should explore the feasibility of intensive measurement-informed lifestyle interventions.

Germline pathogenic variants in the RUNX1 gene lead to the condition RUNX1-familial platelet disorder (RUNX1-FPD). This condition is associated with a 30%-50% lifetime risk of hematologic malignancies, including acute myeloid leukemia. In addition to physical manifestations including prolonged bleeding and easy bruising, individuals with RUNX1-FPD face profound psychosocial challenges. Individuals 18-39 years old may particularly struggle in their experiences with RUNX-FPD as they navigate developmental milestones. This descriptive, cross-sectional study includes participants aged 18-39, enrolled in the NIH RUNX1 Natural History Study (19-HG-0059). Each participant completed a structured psychosocial self-report assessment that included demographic factors, patient-reported outcomes on mental health symptomatology, psychiatric treatment history, and traumatic stress symptomatology. Open-ended questions asked participants to identify the most difficult part of living with RUNX1-FPD and how RUNX1-FPD has impacted their lives. Twenty-two participants completed the measures and were included in the analyses. Participants' mean age was 31 years (SD = 5.1). Fifty percent of participants reported higher than average anxiety scores, 59% reported they had been treated by a mental health professional, and 64% reported traumatic stress symptomatology. Living with the chronic uncertainty of cancer development and overall distress from recommended lifelong monitoring processes emerged as themes from the illustrative exemplar quotes. With this study, we describe the significant psychosocial and mental health challenges that emerging adults with RUNX1-FPD face. Access to psychological counseling, peer support groups, and genetic counseling can help individuals process their risk, manage anxiety, and make informed decisions. More research is needed to explore effective coping strategies, resilience-building techniques, and patient-centered resources to improve quality of life for those living with a hereditary predisposition to hematologic malignancies.

High rates of interpersonal violence exposure and trauma-related mental health concerns among women in substance use treatment underscore the need for violence prevention services in these settings. Peer support specialists can play a crucial role in increasing access to trauma-focused services and overcoming barriers, such as stigma and mistrust in formal systems. We tested the feasibility, acceptability, and preliminary efficacy of a peer-delivered sexual and intimate partner violence prevention program for women in substance use treatment (THRIVE: The Healthy Relationships and Interpersonal Violence Education program). We conducted a single-arm trial with 90 women recruited from outpatient and residential substance use treatment centers. Self-report surveys assessed risk and protective factors and violence exposure over four assessment points from baseline (T1) to 3-month follow-up (T4). Exit interviews and survey data examined feasibility and acceptability outcomes. Results from linear mixed models indicated that participants improved on knowledge of consent (M_T1 = 4.37, M_T4 = 4.52), p = .004, and resources (M_T1 = 2.09, M_T4 = 2.63), p < .001; increased sexual self-efficacy (M_T1 = 4.90, M_T4 = 5.29), p < .001; and decreased risky dating (M_T1 = 3.37, M_T4 = 2.87), p < .001, and physical and psychological intimate partner violence victimization (T1: 73.9%, T4: 42.0%), p < .001. Participants reported high satisfaction and acceptability and highlighted the strengths of peers as facilitators. In sum, THRIVE offers promise as an effective, scalable violence prevention program.

Intrinsic capacity (IC), proposed by the World Health Organization, reflects the composite of an individual's physical and mental capacities and is considered a key indicator of healthy aging. Although air pollution has been associated with multiple adverse health outcomes, evidence on its relationship with IC-a multidimensional indicator of overall functional ability-remains limited.

This study aimed to examine the longitudinal associations between long-term exposure to particulate matter of different sizes (PM₁, PM_2.5 and PM₁₀) and declines in intrinsic capacity among middle-aged and older adults in mainland China.

Data were obtained from the nationally representative longitudinal cohort of the China Health and Retirement Longitudinal Study (CHARLS), including adults aged ≥ 45 years. Annual average concentrations of PM₁, PM_2.5 and PM₁₀ were estimated using satellite-based models based on participants' residential locations. A composite IC score was constructed according to the WHO intrinsic capacity framework. Multivariable logistic regression models were used to evaluate associations between particulate matter exposure and IC decline. Restricted cubic spline models were applied to assess nonlinear dose-response relationships. Mixed-exposure effects were further evaluated using weighted quantile sum regression, Bayesian kernel machine regression and quantile g-computation.

Long-term exposure to PM₁, PM_2.5 and PM₁₀ was significantly associated with a higher risk of IC decline and lower composite IC scores. Nonlinear dose-response relationships were observed between particulate matter exposure and IC decline. In mixed-exposure analyses, PM₁₀ and PM_2.5 showed the strongest contributions to the joint effects, with PM₁₀ having the highest weight and posterior inclusion probability. Each one-quantile increase in the overall pollutant mixture was significantly associated with a decline in composite IC scores.

Postpartum depression (PPD) is a significant public health concern in the United States, affecting many women after childbirth and contributing to adverse maternal and infant outcomes. This study aimed to synthesize current evidence on the epidemiology, risk factors, and management of PPD, with particular attention to emerging therapeutic and digital care approaches. A systematic search of major databases identified 25 eligible studies published between 2010 and 2026. The findings indicate that PPD remains prevalent, with disparities strongly associated with race, socioeconomic status, and access to care. Risk factors are multifactorial and include prior mental illness, low social support, unintended pregnancy, and psychosocial stressors, with growing evidence also pointing to genetic contributions. Symptoms may emerge at different stages of the postpartum period, underscoring the importance of ongoing screening rather than a single assessment. While psychotherapy and antidepressant therapy remain the foundation of treatment, newer strategies such as telehealth, mobile health applications, and wearable technologies show promise in improving early detection and access to care. Overall, addressing PPD requires integrated, equitable, and patient-centered approaches to improve maternal and child health outcomes.

Deliberate self-harm (DSH) is a significant but underreported public health concern in Bangladesh, driven by mental health stigma, cultural and legal barriers, and absence of national data. Despite clear links to multiple risk factors, the prevalence and determinants of DSH lack systematic exploration. This narrative review synthesizes existing research articles and gray literature to summarize DSH behaviors, prevalence, risk factors, and key correlates within the Bangladeshi population.

PubMed, EMBASE, Scopus, PsycInfo, Google Scholar, and BanglaJOL were searched from their inception to identify research articles on risk factors and correlates of DSH behaviors. Studies assessing DSH behaviors and reporting associated risk factors in Bangladeshi populations were included for this review.

12 cross-sectional studies (1995-2025) with sample sizes between 51 and 383 were included. Nine studies were hospital based, while three were conducted in community settings among LGBT, homosexual male, and university students. Seven reported DSH behaviors in participants aged 14-65 years, and five assessed co-occurring mental disorders. Reported lifetime DSH prevalence was 17% (95% CI: 12-22.5) among university students, 40.2% in homosexual men, and 56%-62% among homosexual women. The most common methods were self-cutting (39%), medication overdose (38%), and hanging (31%). Overall, 71% had at least one psychiatric disorder. Half of those with planned DSH intended to die, while 12% sought escape. Depressive and anxiety disorders, familial history, medical comorbidities, personality disorder, relationship problems, and poor family interactions were significant risk factors. DSH was positively associated with suicidal attempts, with 34.2% of individuals with DSH reporting a lifetime suicide attempt.

The review outlined limited studies on DSH among the Bangladeshi population. This gap warrants further large-scale studies to find the temporal relation between DSH and its correlates among the community population in Bangladesh.

Despite the well-documented efficacy of exposure therapy for phobic disorders, its real-world implementation remains limited due to barriers in accessibility, acceptability, and generalization.

This proof-of-concept study examined the feasibility and preliminary effects of a novel gamified augmented reality (AR) intervention designed to support in vivo exposure by embedding playful, non-threatening virtual stimuli into real-world anxiety-provoking contexts.

Twenty individuals with various phobic disorders participated in a multiple-baseline design. At a randomly assigned time point, participants used a smartphone-based AR application, or in some cases, a VR headset version, to interact with virtual game elements within individualized fear-relevant environments. The task involved physically navigating individualized fear-relevant environments while collecting color-coded virtual objects presented via augmented reality within the real-world setting.

Linear mixed-effects analyses indicated a significant reduction in self-reported situational fear following the intervention, with a large within-subject effect size estimate (Cohen's d = 2.21). Secondary outcomes related to anxiety sensitivity, agoraphobic cognitions, and depressive symptoms also showed pre-post improvements with small to moderate effect sizes. No significant differences were observed across device types or treatment settings.

The findings provide preliminary support for a low-threshold, smartphone-based AR approach that may complement exposure-based interventions in naturalistic settings. However, given the small and heterogeneous sample and the absence of a control group, these results should be interpreted cautiously. Future randomized controlled studies with larger and more homogeneous samples, validated behavioral outcome measures, and follow-up assessments are needed to clarify efficacy, mechanisms of change, and long-term effects.

One in four university students face mental health challenges, underscoring the need for effective support systems. Within Erasmus University Rotterdam student wellbeing initiative, we developed a mobile intervention providing universal and targeted preventive support, focusing on emotion regulation to address common issues like depression and anxiety. This study reports a superiority Randomized Controlled Trial evaluating intervention impact and uptake among students with elevated stress.

(N = 202) were randomized to immediate ROOM app access (n = 101) or a 3 month waitlist control (n = 101); 171 (85%) completed the trial. Questionnaires were completed at baseline and weeks 3, 8, and 12, alongside continuous in-app activity logs. Primary outcomes were perceived stress and emotion regulation; secondary outcomes included depressive and anxiety symptoms, resilience, and objective and subjective engagement. Analyses followed an intent-to-treat approach, with exploratory subgroup analyses assessing differences by engagement level.

The intervention showed no statistically significant impact on any outcomes. Exploratory analyses suggested that higher engagement with the intervention was associated with greater reductions in stress. Engagement was initially high but declined sharply after week 1, stabilizing by week 6. More than half of participants still used the intervention at day 30. Breathing and relaxation exercises were favoured, whereas transfer-elements and self-assessments were used less than expected.

ROOM did not demonstrate significant effects at the sample level, although greater engagement was associated with reduced stress. Future research is needed to better understand what drives engagement with the intervention, strengthen real-world skill application, and evaluate its preventive potential in larger and more representative student samples.

Anti-amyloid therapies (AATs) for Alzheimer's disease (AD) demonstrate modest benefit in trials, but real-world eligibility remains uncertain. Requirements including biomarker confirmation and safety exclusions may limit access.

Using the Brains for Dementia Research cohort, we linked longitudinal cognitive data with post mortem neuropathology to estimate trial-like AAT eligibility. Early stage was defined using harmonized cognitive thresholds. AD pathology required Thal amyloid phase ≥3 and Braak stage ≥IV. Exclusions were applied hierarchically: (1) vascular neuropathology, (2) anticoagulant use, and (3) apolipoprotein E (APOE) ε4/ε4 homozygosity.

Of 1230 participants, 945 had sufficient data; 232 had early, pathology-confirmed AD. Vascular pathology excluded 70.7%, anticoagulant use 19.1%, and APOE ε4/ε4 homozygosity 3.6% of remaining cases. Overall, 53 individuals (4.3% of those screened) were eligible. Eligibility declined with age and was driven primarily by vascular comorbidity.

Using a conservative pathology-anchored framework, only a small proportion of this older brain-donor cohort met trial-like eligibility criteria.