Individuals with major depressive disorder (MDD) typically present subclinical symptoms even during remission. Evidence from the Dual Continua Model (DCM), the recent view of mental health as a dynamic balance condition, and the emphasis on the role of internal and external challenges and resources in sustaining or hindering mental health suggest that the joint investigation of positive mental health (PMH) and mental illness among persons with MDD in remission provides a comprehensive assessment of both lingering symptomatology and daily functioning. Through this integrated framework the time-budget and associated experience of persons with MDD in remission were investigated.

67 clinically stable participants (Mage = 48.7) completed the Beck Depression Inventory-IIand the Mental Health Continuum-SF. Three different profiles were identified: sustainable balance (high PMH, low depression), disruptive imbalance (low/moderate PMH, high depression) and precarious balance (low/moderate PMH and low depression; high PMH and high depression). Moreover, through an Experience Sampling procedure, during one week participants provided 2067 real-time self-reports about daily activities and associated experience.

No group difference emerged in daily activity distribution. Multilevel regression models however revealed that, compared to the precarious balance group, the quality of experience was globally poorer in the disruptive imbalance group, and significantly better in the sustainable balance group.

Within an integrative model of mental health as a condition of dynamic balance or imbalance that includes both positive mental health and clinical symptoms, findings can offer fruitful suggestions for intervention aimed at promoting daily psychosocial functioning among persons with MDD in remission.

Mortality in psychiatric hospitals is both elevated and poorly understood. We aimed to address a knowledge gap about cause-specific mortality among current psychiatric inpatients using a meta-analytic synthesis of primary research reporting on the natural, unnatural, and cause-specific mortalities.

We conducted a systematic review and meta-analysis according to PRISMA and MOOSE guidelines. Searches for peer reviewed English language papers published between 1 January 1960 and 24 July 2025 and indexed in MEDLINE, PsycINFO, EMBASE and PubMed were supplemented using searches of grey literature and hand searches of reference lists. Data were pooled using random effects meta-analysis. Mortalities were assessed by cause-specific estimates of. i) the percentage of deaths, ii) mortality per 10,000 admissions and iii) mortality rates per 100,000 person-years. Temporal trends were examined using mixed effects meta-regression. A mixed effects model was used to examine subgroups within each mortality according to publication date and the national income of the study setting. This study is registered with PROSPERO (CRD42024572461).

Thirty-eight studies published from diverse geographic settings over the last five decades were included in a meta-analysis of the percentage of mortality according to cause. Of these, twenty-eight studies were included in a meta-analysis of the mortality per 10,000 admissions and twenty-five studies were included in a meta-analysis of mortality rates per 100,000 patient-years. Natural causes accounted for 81.6% (95% confidence interval (CI) 75.7-86.3%, I-square = 98.5) of inpatient deaths. Vascular causes accounted for 31.0% (95% CI, 27.0-35.2%) of deaths, and infection accounted for 17.8% (CI 11.8-26.0%), The pooled estimate of natural deaths per 10,000 admissions was 78.9 (95% CI, 43.1-143.9, I-square = 99.8), falling from 246.6 (95% CI, 132.9-453.1) in pre-2000 studies to 35.2 (95% CI, 18.8-65.8) in more recent studies. The pooled estimate of the natural mortality rate per 100,000 patient-years was 2905.0 (95% CI, 2350.8-3459.2, I-square = 99.4), with rates falling from 5445.4 (95% CI, 4460.9-6429.9) in pre-2000 studies to 1374.3 (95% CI, 968.3-1780.2) in more recent studies. Suicides and accidents respectively accounted for 4.8% (95% CI, 3.0-7.7%) and 3.3% (2.3-4.7%) of deaths. Unnatural mortality rates have been stable over time. All mortality measures had high between study heterogeneity that was not well explained by the available moderators of year of publication and national income of the study setting.

Mortality rates in psychiatric hospitals are highly heterogeneous but have been falling over time. Most inpatient deaths have a natural cause. Our findings suggest a need for primary research examining the demographic and diagnostic associations with inpatient mortality, while underscoring the opportunities for better integration of medical and mental health care.

None.

Engagement with arts and cultural activities has been increasingly recognized for its role in promoting mental health and well-being. This study evaluates the impact of a structured museum-based intervention on psychological well-being.

A prospective hybrid type-1 non-randomized follow-up study with a pre-post design was conducted. Psychological distress, depressive symptoms, anxiety symptoms, and psychological well-being were assessed before and after a structured museum itinerary.

A total of 103 participants (82.5% female) completed pre- and post-intervention assessments. The intervention led to significant improvements across all psychological measures (p < 0.001), with the most notable effects observed in individuals aged 41-60. Additionally, between 89 and 98% of participants reported high acceptability, appropriateness, and feasibility of the itinerary.

The observed clinical improvements and high acceptability highlight the potential of museum-based interventions as an innovative and effective approach to mental health promotion. Future research should focus on scaling and replicating such interventions in diverse cultural and community settings, further integrating the arts into public health strategies.

Psychedelic-assisted therapy is a remarkably promising treatment for substance use disorders and for alcohol use disorder (AUD) in particular. Research supporting psychedelics as a safe and effective pharmacotherapy for AUD and its comorbid psychiatric conditions dates from the late1940s and includes over 2,000 published studies. There are, however, challenges to the clinical implementation of psychedelics on a scale appropriate to a highly prevalent disease. Virtual reality applications can aid in meeting these challenges. Studies have shown that virtual reality simulations of psychedelic phenomenology (VRP) can replicate neurophysiological and behavioral markers of classic serotonergic psychedelics when viewed by healthy subjects. The results of these studies suggest VRP may have utility as an adjunct to or replacement for aspects of psychedelic-assisted therapy. Here, we introduce four potential clinical applications for VRP in psychedelic-assisted therapy: to prepare for psychedelics, to extend and enhance their efficacy, to facilitate integration following psychedelic dosing, and to standardize the set and setting. VRP may also have application to clinical research in psychedelics as a placebo and as a tool for interrogating the subjective experience of psychedelics in the therapeutic setting. Integrating virtual reality into psychedelic therapy and research holds the promise of new possibilities for psychedelic treatment and new pathways to their implementation.

In March 2020, the World Health Organization declared the SARS-CoV-2 outbreak a pandemic. In France, this led to school closures and strict lockdown measures. This unprecedented context disrupted the social lives and mental health of children and liadolescents.

CONFEADO is a nationwide cross-sectional study designed to assess psychological distress in relation to coping strategies and emotional factors. Conducted between June 9 and September 14, 2020, the study included children aged 9 to 18 and their parents, including youth in child welfare services, all of whom provided informed consent. Data were collected via a self-administered, ad hoc web-based questionnaire distributed through national institutions, associations, and social media. For children in welfare services, a paper version was completed with the assistance of childcare professionals. The primary outcome was psychological distress, measured using the Children and Adolescents Psychological Distress Scale-10 (CAPDS-10). Additional variables included coping strategies (behavioral, cognitive, emotional, relational, spiritual), socio-environmental factors (e.g., living in housing with fewer than three rooms, low parental perceived social support), family conflict (e.g., increased conflict or violence), quality of family relationships (e.g., getting along with parents or siblings less than usual), eating habits (e.g., changes in appetite), and school-related stress (e.g., feeling overwhelmed by schoolwork).

A total of 3,148 children and adolescents participated. In bivariate analyses, children who viewed religion as a positive or novel aspect of lockdown (spiritual coping) had a higher likelihood of experiencing moderate distress [OR = 1.26; 95% CI: 0.99-1.60; p = 0.06] and a significantly higher likelihood of experiencing severe distress [OR = 1.99; 95% CI: 1.44-2.74; p < 0.0001]. Relational coping was protective: lower perceived relational support was associated with increased risk of both moderate distress [OR = 0.79; 95% CI: 0.75-0.83; p < 0.0001] and severe distress [OR = 0.55; 95% CI: 0.49-0.61; p < 0.0001]. In multivariate models, severe distress was significantly associated with living in small housing, low parental perceived support, feeling overwhelmed by schoolwork, and appetite changes. Higher levels of behavioral and emotional coping difficulties and increased family conflict were also associated with greater distress.

Coping strategies are key indicators of psychological distress in youth. Assessing how children and adolescents adapt during crises may provide deeper insights than symptom-based approaches alone. The role of spiritual coping in emotional adjustment warrants further clinical and research attention.

The aim of the study was to provide a comprehensive overview of the current application of tools used for assessing neuropsychiatric symptoms (NPSs) in patients with Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and multiple system atrophy (MSA) through bibliometric analysis.

Publications published between 2014 and 2023 were searched using the Web of Science Core Collection database (WoSCC). Only articles and reviews published in the English language were included. CiteSpace was used to analyze the countries, keyword patterns, and reference co-citations. A detailed full-text analysis was further conducted across all studies to assess the usage of NPS assessment tools.

Our analysis included 530 publications demonstrating consistent annual growth, reflecting rising global interest in NPSs within neurodegenerative and neuroinflammatory diseases. However, these studies reveal research deficiency in current assessment methodologies that demands more attention. Research output remains predominantly concentrated in developed nations with aging populations, particularly the USA, which leads in both publication volume and quality. The primary focus of current research involves evaluating the validity of existing assessment tools, while emerging investigations explore next-generation assessment tools designed to enhance diagnostic precision and enable personalized treatment strategies. Despite these advances, widespread clinical adoption remains limited, and further validation studies are required to establish their reliability across diverse populations and disease stages.

This study highlights the growing importance of NPSs in neurodegenerative diseases, particularly in HD, ALS, and MSA. We identify hotspots and deficiencies in the research field of validating NPS assessment tools, integrating NPSs into the diagnostic framework and elucidating neurobiological mechanisms. These findings will contribute to enhanced diagnostic and therapeutic approaches for neurodegenerative diseases.

Electroconvulsive therapy (ECT) has been shown to induce widespread dysregulation of network connectivity in patients with mood disorders. Nevertheless, the extent to which these functional changes contribute to patients' cognitive side-effects or depressive symptoms improvement remains unclear. This study investigated cross-sectional resting-state functional connectivity (rs-FC) differences in patients with mood disorders after their 8th ECT session (ECT group, n = 33) compared to those receiving pharmacological treatment (non-ECT group, n = 36) and healthy controls (n = 34). Furthermore, we explored the association of rs-FC differences with cognitive side-effects and depressive symptom improvements assessed longitudinally in the ECT group. We focused on analyzing rs-FC within- and between the default mode network (DMN), executive control network (ECN), and frontoparietal network (FPN). Additionally, we explored the association between significant rs-FC group differences and verbal memory decline, and depressive symptoms improvement from pre-to post-ECT within the ECT group. ECT-treated patients exhibited hyper-connectivity within the left-hemisphere FPN compared to those on pharmacological treatment, along with hypo-connectivity between ECN and FPN (p-corrected<0.02). Depressive symptoms positively correlated with rs-FC within the right-hemisphere FPN (p-corrected<0.04). Notably, rs-FC differences were unrelated to verbal memory decline or symptom improvement from pre-to post-ECT (p-corrected>0.1). Our findings highlight differences in brain connectivity between remitted patients after ECT and diagnosis-matched patients following standard pharmacological treatment. Further studies are warranted to investigate longitudinal rs-FC effects of ECT to identify biomarkers predictive of treatment response and the risk of cognitive side effects after ECT.

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world and involves impairment of both motor and cognitive functions, significantly affecting the quality of walking and consequently the quality of life of people affected by this disease. This study analyzed the relationship between gait alterations and cognitive deterioration, using validated clinical tests and an innovative indicator, the φ-bonacci gait number, which quantifies gait harmonicity, symmetry, and consistency. Kinematic data collected during the 6-Minute Walk test on 19 people with PD (pwPD) and 15 healthy adults were analyzed. The results highlighted a significant negative correlation between gait harmonicity and cognitive performance (φ-bonacci gait number-Time Up and Go Dual Task; r = 0.797, p < 0.05). Finally, mediation analysis showed that global cognitive function (MoCA) indirectly influences gait harmonicity through TUG-DT. The results suggest that gait in pwPD is strongly modulated by executive-attentional functions, supporting its cognitive modulation rather than a purely automatic nature. This study allowed to explore the complex relationship between cognitive functions and the motor system, deepening how these interactions influence and refine motor behavior. Therefore, rehabilitation programs combining motor exercises and cognitive training could be more effective in improving gait quality, reducing the risk of falls, and improving person's quality of life.

The serrated neoplasia pathway is an alternate route to colorectal cancer (CRC) development where BRAF ^V600E is the most common initiating genetic alteration. BRAF^V600E-driven tumorigenesis requires gene expression changes mediated by activation of the ERK MAPK signaling pathway. However, the key effectors of this process are elusive. Here, we identify the ERK-regulated transcription factor Fosl1, one such effector. We show that Fosl1 is dispensable for the initiation of BRAF^V600E-driven serrated neoplasia in mice but promotes progression of the disease by regulating the expression of genes involved in inflammation, immunity, cell cycle control, fetal-like programming, and gastric metaplasia. Notably, transgenic Fosl1 expression alone was sufficient to induce tumors with a BRAF ^V600E-like serrated morphology and transcriptional profile. These findings reveal a mechanism through which oncogenic BRAF-driven ERK signaling reprograms transcription to drive serrated neoplasia.

Alopecia is a physical and mental health problem affecting all age groups, aesthetically or psychologically. Among its subtypes, androgenetic alopecia (AGA) is the most prevalent. This androgen-dependent, polygenic disease is hereditary and can occur as early as adolescence. Currently available therapies remain largely palliative and are often accompanied by adverse side effects. Here, we constructed a multifunctional system based on tetrahedral framework nucleic acids (tFNAs), in which quercetin was embedded within tFNAs to form a complex termed tFNAs-Que (TQC). We performed multimodal analysis, combined with transcriptomic analysis, to explore the activation and sustainable changes in the hair follicle cycle after TQC treatment. Our results showed that TQC maintained the stability of the epithelial structure and enhanced the regeneration of functional hair follicles by regulating both hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Additionally, we identified a catalytic role of tFNAs. Overall, this study developed a dual-regulated nucleic acid nanoparticle, opening up new avenues for clinical translation in activating, stabilizing, and sustaining the hair cycle.